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CBNU graduate students from School of Dentistry reveal the research about the carcinogenetic protein 

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국제교류부 (hqiof) 2013/03/07 15:40:02
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3446
CBNU graduate students from School of Dentistry reveal the research about the carcinogenetic protein

CBNU graduate students from School of Dentistry have discovered that a certain protein performs a crucial role in cancer occurrence. Through this research, they even provided the basic information on cancer prevention and development of anticancer drug.

 

The students are Ji Ae Shin and Eun Sun Choi. They are the 2nd year Pathology doctoral students in the School of Dentistry. They each have discovered what role the protein, ‘Mcl-1’, plays in cancer occurrence in Oral & Prostate cancer, and what happens to the targeted antitumor mechanism.

 

Ji Ae Shin posted her  research paper on the January Edition of Molecular-Pharmacology.

 

Eun Sun Choi also posted her paper on the 2013 January Edition of Cancer Letters.

 

This research confirmed that the overexpression of MCl-1 Protein is closely related to  tumor occurrence.

 

The research team controlled the manifestation of Mcl-1 by using Mithramycin A and siRNA technology. As a result, the control of Mcl-1 showed anticancer effect in the cell strain of  oral & prostate cancer and in an animal model.

 

This research suggests the possibility of that controlling Mcl-1 will be important for finding the anticancer drug for oral & prostate cancer.

 

Ji Ae Shin and Eun Sun Choi said, “our research discovered the new molecular signaling pathway related to Mcl-1 controlled by Mithramycin A. This discovery will contribute to the development of prevention and medicine for oral & prostate cancer. We will do our best to contribute ourselves to this cause."

 

Ji Ae Shin and Eun Sun Choi have wrote 17(Author: 9, Co-author: 8) and 16(Author: 5, Co-author: 11) SCI(E) papers so far,and they have received many excellent paper awards.

 

 
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